Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures

Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. data adipokine leptin functions as a regulator of growth at multiple levels, systemically locally. So far, it has been shown influences volume mineral density population with metabolic and/or hormonal abnormality. Data concerning values non-obese children fractures are scarce. Methods. This study included 93 long (LBF), 14 short (SBF), 19 healthy children. Leptin concentration was determined two blood samples (day 0 day 21) analyzed according to gender, fracture type, anatomical localization the fracture, topography, callus formation, healing outcome. Results. Children LBF demonstrated significantly increased levels compared control group (both 0/day 21). In group, girls had more than boys. value influenced by since boys humerus femur highest average initial sample. Boys incomplete formation /day 21), elevated boys? intermediary well-formed callus, also callus. Better associated increment concentrations second over Girls partially satisfactorily formed sample group. Conclusion. samples) SBF corresponding controls. highly gender. High or low immediately upon could be used identify groups formation.